We report herein on two male liver transplant (LT) recipients who presented with cyclosporine (CsA)-related gynecomastia 6 and 10 months after transplantation. The clinical workup showed increased luteinizing hormone (LH), associated with a slight reduction in testosterone blood levels in one patient and increased prolactin levels in the other. After excluding concomitant primary endocrine and/or malignant disease, conversion to tacrolimus (TAC) was performed resulting in clinical improvement of gynecomastia and return of hormone blood levels to normal range within 3 months. Our report confirms a putative role of CsA in post-LT gynecomastia, reversible however upon conversion to TAC.

Switch to tacrolimus for cyclosporine-induced gynecomastia in liver transplant recipients

DE SIMONE P;MORELLI, LUCA;MOSCA, FRANCO;FILIPPONI, FRANCO
2005

Abstract

We report herein on two male liver transplant (LT) recipients who presented with cyclosporine (CsA)-related gynecomastia 6 and 10 months after transplantation. The clinical workup showed increased luteinizing hormone (LH), associated with a slight reduction in testosterone blood levels in one patient and increased prolactin levels in the other. After excluding concomitant primary endocrine and/or malignant disease, conversion to tacrolimus (TAC) was performed resulting in clinical improvement of gynecomastia and return of hormone blood levels to normal range within 3 months. Our report confirms a putative role of CsA in post-LT gynecomastia, reversible however upon conversion to TAC.
Iaria, G; Urbani, L; Catalano, G; DE SIMONE, P; Carrai, P; Petruccelli, S; Morelli, Luca; Coletti, L; Garcia, C; Liermann, R; Mosca, Franco; Filipponi, Franco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/205794
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