The association between isolate genotype, defined as in the international spoligotype database SpolDB4, and extrapulmonary tuberculosis was determined among 1009 patients in a population-based, 4-year survey performed in Tuscany, Italy. Extrapulmonary disease occurred in 24.2% of patients. A statistically significant association with extrapulmonary disease was found for the BOVIS (adjusted OR 3.2; 95% CI 1.2-8.1) and for the Central Asian (CAS) lineages (adjusted OR 2.3; 95% CI 1.0-5.1). These findings support the view that Mycobacterium tuberculosis strains within individual genotypic lineages might have evolved unique pathogenic characteristics that are capable of influencing the clinical outcome of the infection.
|Autori:||LARI N; RINDI L; CRISTOFANI R; RASTOGI N; TORTOLI E; GARZELLI C|
|Titolo:||Association of Mycobacterium tuberculosis complex isolates of BOVIS and Central Asian (CAS) genotypic lineages with extrapulmonary disease|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1111/j.1469-0691.2009.02712.x|
|Appare nelle tipologie:||1.1 Articolo in rivista|