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EnglishThe synthetic access of either beta-D-ManNAc-(1->4)-D-Glc (5) is beta-D-TalNAc-(1->4)-D-Glc (6) disaccharides has been effectively improved with respect to previous syntheses (J. Carbohydr. Chem. 2000, 19, 79–91 and 2004, 23, 179–190), optimizing the preparation of suitably protected 4-O-(2-acetamido-2-deoxy-3,4-O-isopropylidene-beta-D-talopyranosyl)-2,3:5,6-di-O-isopropylidene-aldehydo-D-glucose dimethyl acetal derivatives obtained by complete stereoselective LiAlH4 reduction of new 2’-oximino precursors derived from lactose. The affinity of the disaccharides 5 and 6 toward the natural killer cell NKR-P1 and CD69 receptors has been evaluated and discussed.
| Autori interni: | |
| Autori: | ATTOLINO E; BONACCORSI F; CATELANI G; D'ANDREA F; KRENEK K; BEZOUKA K; KREN V |
| Titolo: | Improved Preparation of beta-D-ManNAc-(1-->4)-D-Glc and beta-D-TalNAc-(1-->4)-D-Glc Disaccharides and Evaluation of Their Activating Properties on the Natural Killer Cells NKR-P1 and CD69 Receptors |
| Anno del prodotto: | 2008 |
| Digital Object Identifier (DOI): | 10.1080/07328300802030845 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/206069
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