A new transformation of Kamiya's disulphide (1) into the bromopenam derivative (4) has been carried out by electrolyzing the disulphide (1) in protic solvents in the presence of Me4NBr. The transformation occurs through an intermediate episulphonium-bromide ion pair in which the bromide appears to tightly linked to the sulphur
Interconversion of the thiazine and thiazolidine system of β -lactam antibiotics. Electrochemical cleavage of Kamiya's disulfide promoted by bromide ion
GIORGI, IRENE;
1982
Abstract
A new transformation of Kamiya's disulphide (1) into the bromopenam derivative (4) has been carried out by electrolyzing the disulphide (1) in protic solvents in the presence of Me4NBr. The transformation occurs through an intermediate episulphonium-bromide ion pair in which the bromide appears to tightly linked to the sulphurFile in questo prodotto:
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