This paper reports the synthesis and biological evaluation towards Al and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.

1,2,3-Triazole[4,5-d]pyridazines II. New Derivatives Tested on the Adenosine Receptors

BIAGI, GIULIANA;GIORGI, IRENE;LIVI, ORESTE;SCARTONI, VALERIO;MARTINI, CLAUDIA;MERLINO, STEFANO;PASERO, MARCO
1994

Abstract

This paper reports the synthesis and biological evaluation towards Al and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Scartoni, Valerio; Martini, Claudia; Tacchi, P; Merlino, Stefano; Pasero, Marco
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/206148
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