This paper reports the synthesis and biological evaluation towards Al and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.
1,2,3-Triazole[4,5-d]pyridazines II. New Derivatives Tested on the Adenosine Receptors
BIAGI, GIULIANA;GIORGI, IRENE;LIVI, ORESTE;SCARTONI, VALERIO;MARTINI, CLAUDIA;MERLINO, STEFANO;PASERO, MARCO
1994-01-01
Abstract
This paper reports the synthesis and biological evaluation towards Al and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.File in questo prodotto:
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