The synthesis, unambiguous proof of structure and benzodiazepine receptor affinity and efficacy of 2-phenyl-1,2,4-triazolo[1,5-c] [1,3]benzoxazin-5-one 1 are reported. The in vitro biological data indicate that 1 may be the lead compound of a new class of benzodiazepine antagonist-inverse agonist ligands.
TRICYCLIC HETEROAROMATIC SYSTEMS - 2-PHENYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONE - A NOVEL BENZODIAZEPINE RECEPTOR-LIGAND
MARTINI, CLAUDIA;GIUSTI, LAURA;LUCACCHINI, ANTONIO;
1994
Abstract
The synthesis, unambiguous proof of structure and benzodiazepine receptor affinity and efficacy of 2-phenyl-1,2,4-triazolo[1,5-c] [1,3]benzoxazin-5-one 1 are reported. The in vitro biological data indicate that 1 may be the lead compound of a new class of benzodiazepine antagonist-inverse agonist ligands.File in questo prodotto:
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