Racemic 4,5-disubstitued 5H-furan-2-ones have been selectively synthesized by addition of 1.2-1.6 equiv of aryl, alkenyl or 1-alkynyl halides and catalytic amounts of Pd(OAc)(2) and a soft ligand such as tri-2-furylphosphine or triphenylarsine to the reaction mixtures obtained by treatment of 3-ynoic acids with 1.1 equiv of t-BuOK in DMSO at 20 degrees C. (C) 1998 Elsevier Science Ltd. All rights reserved.
Selective palladium-mediated synthesis of racemic 4,5-disubstituted 5H-furan-2-ones from 3-ynoic acids and organic halides
ROSSI, RENZO;BELLINA, FABIO;
1998-01-01
Abstract
Racemic 4,5-disubstitued 5H-furan-2-ones have been selectively synthesized by addition of 1.2-1.6 equiv of aryl, alkenyl or 1-alkynyl halides and catalytic amounts of Pd(OAc)(2) and a soft ligand such as tri-2-furylphosphine or triphenylarsine to the reaction mixtures obtained by treatment of 3-ynoic acids with 1.1 equiv of t-BuOK in DMSO at 20 degrees C. (C) 1998 Elsevier Science Ltd. All rights reserved.File in questo prodotto:
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