Racemic 4,5-disubstitued 5H-furan-2-ones have been selectively synthesized by addition of 1.2-1.6 equiv of aryl, alkenyl or 1-alkynyl halides and catalytic amounts of Pd(OAc)(2) and a soft ligand such as tri-2-furylphosphine or triphenylarsine to the reaction mixtures obtained by treatment of 3-ynoic acids with 1.1 equiv of t-BuOK in DMSO at 20 degrees C. (C) 1998 Elsevier Science Ltd. All rights reserved.

Selective palladium-mediated synthesis of racemic 4,5-disubstituted 5H-furan-2-ones from 3-ynoic acids and organic halides

ROSSI, RENZO;BELLINA, FABIO;
1998

Abstract

Racemic 4,5-disubstitued 5H-furan-2-ones have been selectively synthesized by addition of 1.2-1.6 equiv of aryl, alkenyl or 1-alkynyl halides and catalytic amounts of Pd(OAc)(2) and a soft ligand such as tri-2-furylphosphine or triphenylarsine to the reaction mixtures obtained by treatment of 3-ynoic acids with 1.1 equiv of t-BuOK in DMSO at 20 degrees C. (C) 1998 Elsevier Science Ltd. All rights reserved.
Rossi, Renzo; Bellina, Fabio; Biagetti, M; Mannina, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/206372
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