This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards A(1)-adenosine receptors. I-Benzyl derivatives bearing new amines and new 1-(substituted benzyl) derivatives were prepared and tested. The biological results showed that some compounds possessed high affinity (approximate to 30-70 nM) and good selectivity toward the A1-adenosine receptors. Further information about structure-biological activity relationships was aquired.

1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives.

GIORGI, IRENE;MANERA, CLEMENTINA;LUCACCHINI, ANTONIO;
1996

Abstract

This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards A(1)-adenosine receptors. I-Benzyl derivatives bearing new amines and new 1-(substituted benzyl) derivatives were prepared and tested. The biological results showed that some compounds possessed high affinity (approximate to 30-70 nM) and good selectivity toward the A1-adenosine receptors. Further information about structure-biological activity relationships was aquired.
Biagi, G; Giorgi, Irene; Livi, O; Scartoni, V; Manera, Clementina; Lucacchini, Antonio; Senatore, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/206393
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