The NM23-Hl gene is a putative tumor suppressor gene that may be important in the metastasic process. Recent genetic and immunological data indicate that the NM23-Hl gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated.
Autori interni: | |
Autori: | Varesco L; Caligo MA; Simi P; Black DM; Nardini V; Casarino L; Rocchi M; Ferrara G; Solomon E; Bevilacqua G |
Titolo: | The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII. |
Anno del prodotto: | 1992 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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