A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid around carbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancer therapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses, while the functionalization degree of 2.33mg of Quercetin per g of composite was assessed by Folin-Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interfere with the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhanced with a recorded IC50 value much lower than free Quercetin. Cell viability test on healthy cells demonstrated no-toxicity of the conjugate

Quercetin nanocomposite as novel anticancer therapeutic: Improved efficiency and reduced toxicity

PARCHI, PAOLO DOMENICO;
2013

Abstract

A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid around carbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancer therapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses, while the functionalization degree of 2.33mg of Quercetin per g of composite was assessed by Folin-Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interfere with the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhanced with a recorded IC50 value much lower than free Quercetin. Cell viability test on healthy cells demonstrated no-toxicity of the conjugate
Cirillo, G; Vittorio, O; Hampel, S; Iemma, F; Parchi, PAOLO DOMENICO; Cecchini, M; Puoci, F; Picci, N.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/208315
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