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EnglishA three-functional nanocomposite was prepared by radical polymerization of methacrylic acid around carbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancer therapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses, while the functionalization degree of 2.33mg of Quercetin per g of composite was assessed by Folin-Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interfere with the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhanced with a recorded IC50 value much lower than free Quercetin. Cell viability test on healthy cells demonstrated no-toxicity of the conjugate
| Autori interni: | |
| Autori: | Cirillo G; Vittorio O; Hampel S; Iemma F; Parchi P; Cecchini M; Puoci F; Picci N |
| Titolo: | Quercetin nanocomposite as novel anticancer therapeutic: Improved efficiency and reduced toxicity |
| Anno del prodotto: | 2013 |
| Digital Object Identifier (DOI): | 10.1016/j.ejps.2013.04.008 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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