The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 mu M was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [H-3]dopamine uptake. Moreover, DDC 1 mu M greatly potentiated cell death induced by glutamate 10 and 50 mu M. (+)MK801, a selective non-competitive antagonist of NMDA receptors, completely prevented the toxicity of the two neurotoxins.
|Autori:||VAGLINI F; PARDINI C; MAGGIO R.; CORSINI GU.|
|Titolo:||Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1016/0006-8993(94)01457-S|
|Appare nelle tipologie:||1.1 Articolo in rivista|