The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 mu M was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [H-3]dopamine uptake. Moreover, DDC 1 mu M greatly potentiated cell death induced by glutamate 10 and 50 mu M. (+)MK801, a selective non-competitive antagonist of NMDA receptors, completely prevented the toxicity of the two neurotoxins.
Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures
VAGLINI, FRANCESCA;PARDINI, CARLA MARIA FRANCESCA;
1995-01-01
Abstract
The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 mu M was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [H-3]dopamine uptake. Moreover, DDC 1 mu M greatly potentiated cell death induced by glutamate 10 and 50 mu M. (+)MK801, a selective non-competitive antagonist of NMDA receptors, completely prevented the toxicity of the two neurotoxins.File in questo prodotto:
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