The cytosolic (cEH) and the microsomal epoxide hydrolase (mEH) hydrolyse styrene oxide and trans-1-phenylpropene oxide with different enantioselectivity and regioselectivity. While mEH always leads to a regiospecific and enantioselective opening at the non-benzylic oxirane carbon, cEH gives a non-regioselective and non-enantioselective attack to styrene oxide and a regiospecific and non-enantioselective snack at the benzylic carbon of 1-phenylpropene oxide.
DIFFERENT ENANTIOSELECTIVITY AND REGIOSELECTIVITY OF THE CYTOSOLIC AND MICROSOMAL EPOXIDE HYDROLASE CATALYZED-HYDROLYSIS OF SIMPLE PHENYL-SUBSTITUTED EPOXIDES
CHIAPPE, CINZIA;
1994-01-01
Abstract
The cytosolic (cEH) and the microsomal epoxide hydrolase (mEH) hydrolyse styrene oxide and trans-1-phenylpropene oxide with different enantioselectivity and regioselectivity. While mEH always leads to a regiospecific and enantioselective opening at the non-benzylic oxirane carbon, cEH gives a non-regioselective and non-enantioselective attack to styrene oxide and a regiospecific and non-enantioselective snack at the benzylic carbon of 1-phenylpropene oxide.File in questo prodotto:
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