Four new derivatives of 8-piperazine ethyl xanthine were synthesized and their bronchospasmolytic activity and A(1)-adenosine affinity were studied. Their relaxant action in the tracheal muscle was lower than that of theophylline and that of theophylline derivatives substituted at the 7-position. Only compound 9, where the methyl group in the 1-position of the theophylline was substituted by an isobutyl group, shows a good affinity towards the A(1)-adenosine receptor.
|Autori:||Corsano S; Strappaghetti G; Scapicchi R; Lucacchini A; Senatore G|
|Titolo:||Structure-activity relationships in a series of 8-substituted xanthines as bronchodilator and A(1)-adenosine receptor antagonists|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1002/ardp.19953280905|
|Appare nelle tipologie:||1.1 Articolo in rivista|