Several 2- or 8-n-alkyl-hypoxanthines and a 2,8-di-n-pentyl-hypoxanthine were synthesized and tested as substrates or inhibitors of Xanthine Oxidase (XO). 8-Alkyl derivatives showed a substrate behaviour, whereas 2-alkyl substituted compounds were non-substrates and inhibitors. 2,8-di-n-pentyl-hypoxanthine was ineffective as inhibitor. The comparison between their activity allowed us to conclude that the complexes formed by the enzyme and the cited n-alkylhypoxanthines or 2-n-alkyl-8-azahypoxanthines involve their N(3) and N(9) positions in all the cases. The position of the n-alkyl chain determines the disposition of the molecule inside the complex: 2-n-alkyl-hypoxanthines and 2-n-alkyl-8-azahypoxanthines gave complexes with the same orientation of heterocyclic moieties, opposite that given by 8-n-alkyl-hypoxanthines.
|Autori:||Biagi G; Giorgi I; Livi O; Scartoni V; Lucacchini A; Tonetti I|
|Titolo:||Xanthine Oxidase (XO): Relative Configuration of Complexes Formed by the Enzyme, 2- or 8-n-Alkyl-hypoxanthines and 2-n-Alkyl-8-azahypoxanthines. XII|
|Anno del prodotto:||1993|
|Appare nelle tipologie:||1.1 Articolo in rivista|