Synthesis of N(6)-Substituted 2-Phenyl-8-Azaadenosines. Their Affinity for Adenosine A1 and A2 Receptors: a  Comparison with the Corresponding 2-Phenyl-9-Benzyl-8-Azaadenines.

Biagi, G; Giorgi, Irene; Livi, O; Scartoni, V; Lucacchini, Antonio; Martini, Claudia; Tacchi, P.

Comparison of the affinity towards adenosine receptors of 2-phenyl-8-azaadenosines, bearing a lipophilic substituent on N(6), with the corresponding 2-phenyl-8-azaadenines was carried out. The compounds have good A(1) affinity and high A(1) selectivity. The obtained Ki(rib)/Ki(benz) ratios for A(1) receptors, which showed variable values depending on the structure of the N(6) Substituent,confirmed that 2-phenyl-8-azaadenines are characterized by greater freedom inside A(1) receptors. This situation may be a favourable test of the hypothesized double disposition of these exogenous molecules within A(1) receptors.

Autori:	Biagi G GIORGI, IRENE Livi O Scartoni V LUCACCHINI, ANTONIO MARTINI, CLAUDIA Tacchi P. mostra contributor esterni nascondi contributor esterni
Autori:	Biagi G; Giorgi I; Livi O; Scartoni V; Lucacchini A; Martini C; Tacchi P
Titolo:	Synthesis of N(6)-Substituted 2-Phenyl-8-Azaadenosines. Their Affinity for Adenosine A1 and A2 Receptors: a Comparison with the Corresponding 2-Phenyl-9-Benzyl-8-Azaadenines.
Anno del prodotto:	1995
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11568/22399

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