Overproduction of IL-18 has been described in chronic urticaria. To evaluate free IL-18 and IL-33 in chronic spontaneous urticaria (CSU). IL-18, its inhibitor IL-18BP, IL-33 and its soluble receptor ST2 (sST2) were measured (ELISA) in the sera of 73 CSU patients. Free IL-18 was calculated (law of mass action). Autologous serum skin test (ASST) was performed in all patients. Total IL-18, IL-18BP and free IL-18 serum levels were significantly higher in CSU than in controls. IL-18 and IL-18BP increased significantly in both ASST-positive and negative subgroups. Free IL-18 resulted significantly higher in the ASST-negative, but not in the ASST-positive subgroup. No differences in IL-33/sST2 levels were detected between CSU and controls. Increased levels of free IL-18 and IL-18BP, but not IL-33, was detected in CSU. Whether IL-18 up-regulation is a consequence of inflammation or one of the causes of the pathology needs to be addressed.
|Autori:||Puxeddu I; Italiani P; Giungato P; Pratesi F; Panza F; Bartaloni D; Rocchi V; Del Corso I; Boraschi D; Migliorini P|
|Titolo:||Free IL-18 and IL-33 cytokines in chronic spontaneous urticaria.|
|Anno del prodotto:||2013|
|Digital Object Identifier (DOI):||10.1016/j.cyto.2013.01.015.|
|Appare nelle tipologie:||1.1 Articolo in rivista|