The rabbit liver microsomal P-450 catalyzed oxidation of styrene (1a) and isomeric phenylpropenes, trans-1-phenylpropene (1b), cis-1-phenylpropene (1c) and 3-phenylpropene (1d), was investigated and the enantioselectivity of the epoxidation of the olefinic double bond was determined by checking the enantiomeric excesses of the corresponding first formed epoxides (2). These enantiomeric excesses were always modest, ranging between 7% of (1S,2S)-(2b) and 22% of (1R,2R)-(2c). In the case of (1d) a non-enantioselective hydroxylation at the benzylic-allylic C(3) was also observed. The ratio between this hydroxylation and olefin epoxidation of (1d) was 1:2.
|Autori interni:||CHIAPPE, CINZIA|
|Autori:||BELLUCCI G; CHIAPPE C; CORDONI A; MARIONI F|
|Titolo:||ENANTIOSELECTIVITY IN THE RABBIT LIVER MICROSOMAL BIOTRANSFORMATION OF STYRENE AND PHENYLPROPENES|
|Anno del prodotto:||1994|
|Digital Object Identifier (DOI):||10.3109/10242429409065225|
|Appare nelle tipologie:||1.1 Articolo in rivista|