A genetic vaccine targeting dog telomerase (dTERT) based on the Ad (Adenovirus) prime DNA-EGT (DNA electro-gene -transfer) boost technology can induce strong immune response and increase overall survival (OS) of dogs affected by B-cell malignant lymphoma (ML) when combined to COP therapy in a pilot study. In this study we have continued this treatment of ML patients and evaluated the immunotherapy in dogs affected by other tumor types, such as mesothelioma, hemangiosarcoma, melanoma, T-cell ML and renal cancer.

Safety and Efficacy of a Genetic Vaccine targeting Telomerase against various canine cancers

GAVAZZA, ALESSANDRA;LUBAS, GEORGE;
2012

Abstract

A genetic vaccine targeting dog telomerase (dTERT) based on the Ad (Adenovirus) prime DNA-EGT (DNA electro-gene -transfer) boost technology can induce strong immune response and increase overall survival (OS) of dogs affected by B-cell malignant lymphoma (ML) when combined to COP therapy in a pilot study. In this study we have continued this treatment of ML patients and evaluated the immunotherapy in dogs affected by other tumor types, such as mesothelioma, hemangiosarcoma, melanoma, T-cell ML and renal cancer.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/231021
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