This paper describes the preparation of title compounds starting from 3-benzyl-4-amino-5-carboxyamidothiazole-2(3H)-thione, which, by heating with alkyl orthobenzoates, was converted into 3-benzyl-5-phenyl-7-alkoxy-thiazolo[4,5-d]pyrimidines. The treatment of these compounds with hydrobromic acid in acetic acid gave 3-benzyl-5-phenyl-7-oxo-thiazolo[4,5-d]pyrimidine-2(3H)-thione which, by reaction with phosphorus oxychloride and subsequent substitution of the halogen with amines, gave the corresponding title compounds.
Autori interni: | |
Autori: | Biagi G; Giorgi I; Livi O; Scartoni V |
Titolo: | Synthesis of New 3-Benzyl-5-Phenyl-7-Alkylaminothiazolo[4,5-d]pyrimidine-2(3H)-Thiones.) |
Anno del prodotto: | 1995 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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