This paper describes the preparation of title compounds starting from 3-benzyl-4-amino-5-carboxyamidothiazole-2(3H)-thione, which, by heating with alkyl orthobenzoates, was converted into 3-benzyl-5-phenyl-7-alkoxy-thiazolo[4,5-d]pyrimidines. The treatment of these compounds with hydrobromic acid in acetic acid gave 3-benzyl-5-phenyl-7-oxo-thiazolo[4,5-d]pyrimidine-2(3H)-thione which, by reaction with phosphorus oxychloride and subsequent substitution of the halogen with amines, gave the corresponding title compounds.
|Autori:||Biagi G; Giorgi I; Livi O; Scartoni V|
|Titolo:||Synthesis of New 3-Benzyl-5-Phenyl-7-Alkylaminothiazolo[4,5-d]pyrimidine-2(3H)-Thiones.)|
|Anno del prodotto:||1995|
|Appare nelle tipologie:||1.1 Articolo in rivista|