In this prospective, case-control genetic study, 120 consecutive neovascular age-related macular degeneration (AMD) cases and 78 controls were enrolled. Two SNPs (rs2071559 and rs1870377) of VEGF-A receptor-2 (VEGFR-2) gene were analyzed with the technique of Real-Time PCR to investigate a genetic link between AMD and VEGFR-2 gene polymorphisms in Italian patients. The frequency of the VEGFR-2 genotype rs2071559 AA was significantly lower (18.33\%) in patients with AMD than in the control subjects (34.62\%; P = 0.0095, chi-square test; P(corr) = 0.038; OR = 0.42, 95\% CI 0.22 to 0.82). In conclusion, although with the limitations of a small sample size and the few SNPs studied, this study demonstrates a lower frequency of VEGFR-2 rs2071559 AA genotype in an AMD patient population, suggesting future studies on the role VEGFR-2 SNPs.
|Autori interni:||ORLANDI, PAOLA|
DI DESIDERO, TERESA
|Autori:||S. Lazzeri;P. Orlandi;M. Figus;A. Fioravanti;E. Cascio;T. Di Desidero;E. Agosta;B. Canu;M. S. Sartini;R. Danesi;M. Nardi;G. Bocci|
|Titolo:||The rs2071559 AA VEGFR-2 genotype frequency is significantly lower in neovascular age-related macular degeneration patients.|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1100/2012/420190|
|Appare nelle tipologie:||1.1 Articolo in rivista|