The skin penetration of roxithromycin was studied in 27 surgical patients treated with 300 mg orally followed by three oral doses of 150 mg 12-hourly. Peak plasma and skin concentrations of 7.9 +/- 1.2 mg/l and 31.3 +/- 3.7 mg/kg occurred 2.5 and 4 h after last dosing respectively. The plasma and skin half-lives were 7.7 and 6.0 h, and the mean plasma and skin area under the curve values were 64.3 mg/l.h and 155.3 mg/kg.h. Skin/plasma concentration ratios were 4.9 +/- 0.5, 9.7 +/- 1.2, 7.6 +/- 0.8 and 5.9 +/- 1.1, at 3, 4, 5 and 6 h after last dosing respectively. These results demonstrate that roxithromycin achieves high levels in human skin.
|Autori interni:||CAMPA, MARIO|
DI STEFANO, ROSSELLA
|Autori:||M. Campa; I. Zolfino; S. Senesi; N. Bernardini; R. Danesi; M. Ducci; M. Oleggini; R. Di Stefano; F. Mosca; A. Lazzarini|
|Titolo:||The penetration of roxithromycin into human skin.|
|Anno del prodotto:||1990|
|Digital Object Identifier (DOI):||10.1093/jac/26.1.87|
|Appare nelle tipologie:||1.1 Articolo in rivista|