Mutagenicity of hexahydrophenanthrenes and their oxirane derivatives

Crotti, P.; Di Bussolo, V.; Benetti, D.; Longo, V.; Gervasi, P.G.

The mutagenicity of some hexahydrophenanthrenes and their corresponding arene oxides was assayed in histidine-dependent mutants of Salmonella typhimurium TA98 and TA100. All the arene epoxides examd. were devoid of mutagenic activity, although some of them could alkylate nicotinamide. By contrast, the 1,2,3,9,10,10a-hexahydrophenanthrene, trans-1,2,3,4,4a,10a-hexahydrophenanthrene, 9-methyl- and 6-methoxy-trans-1,2,3,4,4a,10a-hexahydrophenanthrene, 7-bromo-trans-1,2,3,4,4a,10a-hexahydrophenanthrene and 9-methyl-trans-1,2,3,4,4a,10a-hexahydrophenanthrene were active as mutagens

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/23778

Autori interni:	CROTTI, PAOLO DI BUSSOLO, VALERIA
Autori:	P. Crotti; V. Di Bussolo; D. Benetti; V. Longo; P.G. Gervasi
Titolo:	Mutagenicity of hexahydrophenanthrenes and their oxirane derivatives
Anno del prodotto:	1994
Appare nelle tipologie:	1.1 Articolo in rivista

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