The mutagenicity of some hexahydrophenanthrenes and their corresponding arene oxides was assayed in histidine-dependent mutants of Salmonella typhimurium TA98 and TA100.  All the arene epoxides examd. were devoid of mutagenic activity, although some of them could alkylate nicotinamide.  By contrast, the 1,2,3,9,10,10a-hexahydrophenanthrene, trans-1,2,3,4,4a,10a-hexahydrophenanthrene, 9-methyl- and 6-methoxy-trans-1,2,3,4,4a,10a-hexahydrophenanthrene, 7-bromo-trans-1,2,3,4,4a,10a-hexahydrophenanthrene and 9-methyl-trans-1,2,3,4,4a,10a-hexahydrophenanthrene were active as mutagens

Mutagenicity of hexahydrophenanthrenes and their oxirane derivatives

CROTTI, PAOLO;DI BUSSOLO, VALERIA;
1994-01-01

Abstract

The mutagenicity of some hexahydrophenanthrenes and their corresponding arene oxides was assayed in histidine-dependent mutants of Salmonella typhimurium TA98 and TA100.  All the arene epoxides examd. were devoid of mutagenic activity, although some of them could alkylate nicotinamide.  By contrast, the 1,2,3,9,10,10a-hexahydrophenanthrene, trans-1,2,3,4,4a,10a-hexahydrophenanthrene, 9-methyl- and 6-methoxy-trans-1,2,3,4,4a,10a-hexahydrophenanthrene, 7-bromo-trans-1,2,3,4,4a,10a-hexahydrophenanthrene and 9-methyl-trans-1,2,3,4,4a,10a-hexahydrophenanthrene were active as mutagens
1994
Crotti, Paolo; DI BUSSOLO, Valeria; D., Benetti; V., Longo; P. G., Gervasi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/23778
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