BACKGROUND: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. METHODS: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). RESULTS: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. LIMITATIONS: These findings did not survive correction for multiple testing and should be interpreted with caution. CONCLUSION: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.
|Autori:||Niki Antypa;Raffaella Calati;Daniel Souery;Silvia Pellegrini;Othman Sentissi;Daniela Amital;Ulrike Moser;Stuart Montgomery;Siegfried Kasper;Joseph Zohar;Diana De Ronchi;Julien Mendlewicz;Alessandro Serretti|
|Titolo:||Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients|
|Anno del prodotto:||2013|
|Digital Object Identifier (DOI):||10.1016/j.jad.2013.02.036|
|Appare nelle tipologie:||1.1 Articolo in rivista|