Aqueous dispersions of solid lipospheres containing up to 7.5% pilocarpine as lipophilic ion pairs were submitted to a preliminary evaluation. The lipospheres (diameter 75-85 nm) consisted mainly of stearic acid and egg lecithin; pilocarpine base was incorporated as ion pair with mono-octylphosphate, monodecylphosphate and monohexadecylphosphate. The following parameters were investigated: stability constants (β) and lipophilicity of the ion pairs, size, polydispersity and drug content of the lipospheres, pilocarpine release in vitro. The preparations might constitute a promising vehicle for sustained ocular delivery of pilocarpine.
|Autori:||Cavalli, R; Morel, S; Gasco, Mr; Chetoni, Patrizia; Saettone, Mf|
|Titolo:||Preparation and evaluation in vitro of colloidal lipospheres containing pilocarpine as ion pair|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1016/0378-5173(94)00339-7|
|Appare nelle tipologie:||1.1 Articolo in rivista|