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EnglishAqueous dispersions of solid lipospheres containing up to 7.5% pilocarpine as lipophilic ion pairs were submitted to a preliminary evaluation. The lipospheres (diameter 75-85 nm) consisted mainly of stearic acid and egg lecithin; pilocarpine base was incorporated as ion pair with mono-octylphosphate, monodecylphosphate and monohexadecylphosphate. The following parameters were investigated: stability constants (β) and lipophilicity of the ion pairs, size, polydispersity and drug content of the lipospheres, pilocarpine release in vitro. The preparations might constitute a promising vehicle for sustained ocular delivery of pilocarpine.
| Autori interni: | |
| Autori: | Cavalli, R; Morel, S; Gasco, Mr; Chetoni, Patrizia; Saettone, Mf |
| Titolo: | Preparation and evaluation in vitro of colloidal lipospheres containing pilocarpine as ion pair |
| Anno del prodotto: | 1995 |
| Digital Object Identifier (DOI): | 10.1016/0378-5173(94)00339-7 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/24605
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