Twelve hundred patients without liver or heart disease, having a normal sized spleen without focal lesions, were examined by ultrasonography to measure the inner diameter of the splenic vein in relation to possible current or recent recovery from pathologic processes. SVD was measured at the hilum of the spleen with the patients supine. Ten of the patients in whom dilation of the SVD was found, together with a group of healthy controls (25), were subsequently studied with a duplex Doppler analysis to measure the venous outflow from the spleen. The results showed 1,175 spleens (98%) with SVD at the hilum of <8 mm and 25 spleens (2%) with SVD of >8 mm. Twenty-three of 25 patients (92%) with enlarged SVD had recent histories of hematopoietic or infectious diseases. Ten of 23 patients with enlarged SVD were studied further with a Doppler analysis. They demonstrated a rapid splenic blood flow with maximum flow velocities ranging from 14 to 27 cm/sec and high outflow volumes (from 430 to 1,227 ml/min, averaging 786 ml/min +/- 266), both significantly increased in comparison with controls (outflow volume from 200 to 355 ml/min, averaging 274 +/- 40; P < 0.0001). We conclude that dilation of the SVD accompanied by an increased intrasplenic blood flow volume without splenic enlargement would indicate a state of increased perfusion of splenic tissue associated with an immune response, reflecting reaction of the spleen to disease.
|Autori interni:||GALETTA, FABIO|
|Autori:||STELLA SM; GIUNTA S; GALETTA F; CINI G; GIUSTI C|
|Titolo:||DILATION OF VENOUS VESSELS AT THE SPLENIC HILUM IN NORMAL SIZED SPLEENS AS AN INDICATION OF PATHOLOGICAL SPLENIC INVOLVEMENT - PRELIMINARY-RESULTS|
|Anno del prodotto:||1993|
|Appare nelle tipologie:||1.1 Articolo in rivista|