HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.

Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe

CONSOLINI, RITA
2013

Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.
De Luca, A; Dunn, D; Zazzi, M; Camacho, R; Torti, C; Fanti, I; Kaiser, R; Sönnerborg, A; Codoñer, Fm; Van Laethem, K; Vandamme, Am; Bansi, L; Ghisetti, V; van de Vijver, Da; Asboe, D; Prosperi, Mc; Di Giambenedetto, S; De Luca, A; Dunn, D; Zazzi, M; Camacho, R; Torti, C; Fanti, I; Kaiser, R; Sönnerborg, A; Codoñer, Fm; Van Laethem, K; Vandamme, Am; Bansi, L; Ghisetti, V; van de Vijver, Da; Asboe, D; Prosperi, Mc; Di Giambenedetto, S; Collaborators: Giacometti A, SEHERE collaboration in C. h. a. i. n.; Butini, L; del Gobbo, R; Menzo, S; Tacconi, D; Corbelli, G; Zanussi, S; Monno, L; Punzi, G; Maggiolo, F; Callegaro, A; Calza, L; Pristerà, R; Turconi, P; Mandas, A; Tini, S; Zoncada, A; Paolini, E; Amadio, G; Sighinolfi, L; Zuccati, G; Morfini, M; Manetti, R; Corsi, P; Galli, L; Di Pietro, M; Bartalesi, F; Colao, G; Tosti, A; Di Biagio, A; Setti, M; Bruzzone, B; Penco, G; Trezzi, M; Orani, A; Pardelli, R; De Gennaro, M; Chiodera, A; Scalzini, A; Palvarini, L; Almi, P; Todaro, G; Monforte, Ad; Cicconi, P; Rusconi, S; Gismondo, Mr; Gismondo, Mr; Micheli, V; Biondi, Ml; Gianotti, N; Capetti, A; Meraviglia, P; Boeri, E; Mussini, C; Pecorari, M; Soria, A; Vecchi, L; Santirocchi, M; Brustia, D; Ravanini, P; Dal Bello, F; Romano, N; Mancuso, S; Calzetti, C; Maserati, R; Filice, G; Baldanti, F; Francisci, D; Parruti, G; Polilli, E; Sacchini, D; Martinelli, C; Consolini, Rita
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/255155
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