Recent data suggest that IL-1-like molecules have been conserved during evolution. The signal transduction mechanism of IL-1 is not known, but kinase activation has been reported. With the aim of studying if human IL-1 has any effect on the leech nervous system, we have added this cytokine to segmental ganglia labeled with [32P]ortophosphoric acid; proteins have been separated by electrophoresis and phosphoproteins detected by autoradiography. In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin.
|Autori:||Bottai, D.; GARCIA GIL, MARIA de las MERCEDES; Zaccardi M., L; Fineschi, L; Brunelli, M.|
|Titolo:||Interleukin-1 and interleukin-6 modify protein phosphorylation in the central nervous system of Hirudo medicinalis.|
|Anno del prodotto:||1994|
|Appare nelle tipologie:||1.1 Articolo in rivista|