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EnglishCathepsin D expression has been assessed by immunohistochemistry in 108 cases of Non-Small Cell Lung Cancer (NSCLC) and its expression has been related to conventional prognostic factors such as tumor size, tumor grade, histotype and nodal involvement. The cancer cells in 41.6% of the tumors showed a granular, cytoplasmic cathepsin D (C-D) positivity. Moreover, some benign macrofage-like stromal cells expressed similar positivity. The C-D immunoreactivity was significantly associated with non-squamous histotype, small size, less advanced and more differentiated cancers. Additionally, in non-squamous tumors we observed a higher significant expression in early-staged (T1-2, NO) than in more advanced neoplasias. No significant associations were found between C-D and Ki-67, PCNA immunoreactivity, DNA ploidy or flow cytometric S-phase data. These findings suggest that NSCLCs also express C-D but, as previously reported for breast cancers, the immunohistochemical C-D expression has a good prognostic significance unlike the results obtained by cytosolic evaluation.
| Autori interni: | |
| Autori: | FONTANINI G; BIGINI D; VIGNATI S; RIBECHINI A; ANGELETTI CA; PINGITORE R |
| Titolo: | IMMUNOSTAINING OF CATHEPSIN-D IN NONSMALL CELL LUNG-CANCER - CORRELATIONS WITH MORPHOLOGICAL AND BIOLOGICAL PARAMETERS |
| Anno del prodotto: | 1994 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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