The synthesis of 9-(p-carbetoxyphenyl) guanine is reported. The assays carried out on guanine deaminase from rat and rabbit liver and pig brain show that this compound is a powerful inhibitor. The compound has a Ki = 5 uM for the enzyme from pig brain. The use of the inhibitor for the synthesis of a specific adsorbent for guanine deaminase was studied.

POWERFUL INHIBITOR OF GUANINE DEAMINASE

LUCACCHINI, ANTONIO;MONTALI, UMBERTO;
1977-01-01

Abstract

The synthesis of 9-(p-carbetoxyphenyl) guanine is reported. The assays carried out on guanine deaminase from rat and rabbit liver and pig brain show that this compound is a powerful inhibitor. The compound has a Ki = 5 uM for the enzyme from pig brain. The use of the inhibitor for the synthesis of a specific adsorbent for guanine deaminase was studied.
1977
Lucacchini, Antonio; Montali, Umberto; Segnini, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/2752
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