Synopsis The in vitro permeation through excised hairless mouse skin of a series of 4-O-(N, N-dimethylaminoalkyl)-benzophenones, non-quaternarized and quaternarized, and of two commercial benzophenone sunscreens, taken as reference compounds, was investigated. The aim of the study was to verify the skin penetration of the highly skin-substantive quaternary ammonium derivatives, in comparison with their parent, non-quaternarized compounds. While the quaternary derivatives proved unable to permeate the skin during the period of observation (45 h), their parent amine hydrochlorides and the reference sunscreens (2-hydroxy-4-methoxy-benzophenone-5-sulphonic acid and 2,2'-dihydroxy-4,4'-dimethoxy-benzophenone 5,5'-sodium disulphonate), showed appreciable transdermal fluxes. These data indicate that the presence of a quaternary ammonium group in a molecule, besides inducing a high affinity for cutaneous keratin, may result in hindered or reduced transdermal (and possibly systemic) absorption. Both features may contribute in improving the safety of a cosmetic sunscreen.
|Autori:||MONTI D; M.F. SAETTONE; M. CENTINI; C. ANSELMI|
|Titolo:||Substantivity of Sunscreen - "in vitro" evalutation of the transdermal permeation characteristics of some benzophenone derivatives|
|Anno del prodotto:||1993|
|Digital Object Identifier (DOI):||10.1111/j.1467-2494.1993.tb00068.x|
|Appare nelle tipologie:||1.1 Articolo in rivista|