Two new limonoids, 1-O-deacetyl-2α-methoxykhayanolide (1) and kigelianolide (2), together with deacetylkhayanolide E (3), 1-O-deacetyl- 2α-hydroxykhayanolide E (4) and khayanolide B (5) were isolated from the ethyl acetate-soluble fraction of the methanolic extract of Kigelia africana. The structures of these limonoids (1-5) were elucidated by the combination of 1D (1H and 13C NMR) and 2D (HMQC, HMBC and COSY) NMR spectroscopy and mass spectrometry (EIMS, HREIMS), and in comparison with literature data of related compounds. The structure of compound 1 was further confirmed by X-ray crystallography, and the absolute stereochemistry of compounds 1 and 2 was determined by electronic circular dichroism (ECD) spectroscopy. Limonoids 1-5 showed weak inhibitory activities against the enzymes acetylcholinesterase (AChE), butyrycholinesterase (BChE) and lipoxygenase (LOX) in a concentration-dependent manner with IC50 values in the ranges 137.5 -225.2 μM for AChE, 185.4 -241.5 μM for BChE and 281.2 -189.6 μM for LOX.
|Autori:||Bushra Jabeen;Naheed Riaz;Muhammad Saleem;Muhammad Akram Naveed;Maqsood Ahmed;Muhammad Nawaz Tahir;Gennaro Pescitelli;Muhammad Ashraf;Syeda Abida Ejaz;Irshad Ahmed;Abdul Jabbar|
|Titolo:||Isolation and Characterization of Limonoids from Kigelia africana|
|Anno del prodotto:||2013|
|Digital Object Identifier (DOI):||10.5560/ZNB.2013-3096|
|Appare nelle tipologie:||1.1 Articolo in rivista|