Staphylococcus aureus strain Cowan I, a strong polyclonal B-cell activator (PBA), inhibited contact sensitivity to oxazolone in mice when administered 24 hr before sensitization. This suppression was mediated by idiotype-positive (Id+) B lymphocytes, which arose very early during the sensitization process and induced anti-Id B cells. These cells were found at Day 3 of the sensitization process and exerted their effect by activating antigen-specific suppressor T lymphocytes, which affected the efferent phase of the immune response. S. aureus strain Wood 46, which lacks of the ability to act as a PBA, was unable to inhibit contact sensitivity. These results indicate that PBA may play an important role in the regulation of cell-mediated immune reactions.
|Autori interni:||CAMPA, MARIO|
|Autori:||BENEDETTINI G; DELIBERO G; MORI L; MARELLI P; ANGIONI MR; CAMPA M|
|Titolo:||STAPHYLOCOCCUS-AUREUS-INDUCED SUPPRESSION OF CONTACT SENSITIVITY IN MICE - SUPPRESSOR CELLS ELICITED BY POLYCLONAL B-CELL ACTIVATION ARE REGULATED BY IDIOTYPE ANTI-IDIOTYPE INTERACTIONS|
|Anno del prodotto:||1985|
|Digital Object Identifier (DOI):||10.1016/0008-8749(85)90155-8|
|Appare nelle tipologie:||1.1 Articolo in rivista|