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EnglishStaphylococcus aureus strain Cowan I, a strong polyclonal B-cell activator (PBA), inhibited contact sensitivity to oxazolone in mice when administered 24 hr before sensitization. This suppression was mediated by idiotype-positive (Id+) B lymphocytes, which arose very early during the sensitization process and induced anti-Id B cells. These cells were found at Day 3 of the sensitization process and exerted their effect by activating antigen-specific suppressor T lymphocytes, which affected the efferent phase of the immune response. S. aureus strain Wood 46, which lacks of the ability to act as a PBA, was unable to inhibit contact sensitivity. These results indicate that PBA may play an important role in the regulation of cell-mediated immune reactions.
| Autori interni: | |
| Autori: | BENEDETTINI G; DELIBERO G; MORI L; MARELLI P; ANGIONI MR; CAMPA M |
| Titolo: | STAPHYLOCOCCUS-AUREUS-INDUCED SUPPRESSION OF CONTACT SENSITIVITY IN MICE - SUPPRESSOR CELLS ELICITED BY POLYCLONAL B-CELL ACTIVATION ARE REGULATED BY IDIOTYPE ANTI-IDIOTYPE INTERACTIONS |
| Anno del prodotto: | 1985 |
| Digital Object Identifier (DOI): | 10.1016/0008-8749(85)90155-8 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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