Staphylococcus aureus strain Cowan I, a strong polyclonal B-cell activator (PBA), inhibited contact sensitivity to oxazolone in mice when administered 24 hr before sensitization. This suppression was mediated by idiotype-positive (Id+) B lymphocytes, which arose very early during the sensitization process and induced anti-Id B cells. These cells were found at Day 3 of the sensitization process and exerted their effect by activating antigen-specific suppressor T lymphocytes, which affected the efferent phase of the immune response. S. aureus strain Wood 46, which lacks of the ability to act as a PBA, was unable to inhibit contact sensitivity. These results indicate that PBA may play an important role in the regulation of cell-mediated immune reactions.

STAPHYLOCOCCUS-AUREUS-INDUCED SUPPRESSION OF CONTACT SENSITIVITY IN MICE - SUPPRESSOR CELLS ELICITED BY POLYCLONAL B-CELL ACTIVATION ARE REGULATED BY IDIOTYPE ANTI-IDIOTYPE INTERACTIONS

CAMPA, MARIO
1985

Abstract

Staphylococcus aureus strain Cowan I, a strong polyclonal B-cell activator (PBA), inhibited contact sensitivity to oxazolone in mice when administered 24 hr before sensitization. This suppression was mediated by idiotype-positive (Id+) B lymphocytes, which arose very early during the sensitization process and induced anti-Id B cells. These cells were found at Day 3 of the sensitization process and exerted their effect by activating antigen-specific suppressor T lymphocytes, which affected the efferent phase of the immune response. S. aureus strain Wood 46, which lacks of the ability to act as a PBA, was unable to inhibit contact sensitivity. These results indicate that PBA may play an important role in the regulation of cell-mediated immune reactions.
Benedettini, G; Delibero, G; Mori, L; Marelli, P; Angioni, Mr; Campa, Mario
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/3020
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