The aim of the present investigation was to investigate the influence of various polymers at different concentrations on the in vivo activity of pilocarpine-loaded albumin nanoparticles. It was speculated that co-administration with viscous or bioadhesive polymers would increase the time of residence in the eye of the drug-loaded particle systems, and hence the drug bioavailability. For this purpose, different formulations containing bioadhesive (hyaluronic acid, mucin, sodium carboxymethylcellulose, and polyacrylic acid) or viscosity-enhancing polymers (methylcellulose, polyvinyl alcohol, and hydroxypropylmethylcellulose) were tested in rabbits for miotic effect and reduction of intraocular pressure (IOP, betamethasone model). In the presence of some polymers, the nanoparticles induced a significantly improved pharmacological response when compared with particle dispersions in buffer or with particle-free polymeric vehicles. Bioadhesive polymers exhibited superior effects with respect to viscous polymers: the best results for miotic response and IOP reduction were observed with mucin. It can be assumed that co-administration of particles with these polymers leads to an improved adhesion to the precorneal/conjunctival mucin layer and hence to a prolongation of the residence time of the medication in the eye.
|Autori:||Zimmer A., K; Chetoni, Patrizia; Saettone, Mf; Zerbe, H; Kreuter, J.|
|Titolo:||Evaluation of pilocarpine-loaded albumin particles as controlled drug delivery systems for the eye. II. Co-administration with bioadhesive and viscous polymers|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1016/0168-3659(94)00059-4,|
|Appare nelle tipologie:||1.1 Articolo in rivista|