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EnglishFifty-seven patients took part in a controlled double-blind trial between tiopronin and D-penicillamine as basic treatment for rheumatoid arthritis. Thirty-nine (19 receiving tiopronin, 20 receiving D-penicillamine) completed the trial after 1 year. Both drugs resulted in a decrease of the erythrocyte sedimentation rate, Ritchie index, and Lee index and in a sparing effect on symptomatic antiinflammatory therapy. Improvement in these variables was statistically highly significant at any interval with tiopronin, but was sometimes less or not at all significant with D-penicillamine. Nevertheless, the difference in effects between the 2 drugs never reached statistical significance. Six patients receiving tiopronin and 6 receiving D-penicillamine were taken out of the experiment because of side effects.
| Autori interni: | |
| Autori: | PASERO G; PELLEGRINI P; AMBANELLI U; CIOMPI M; COLAMUSSI V; FERRACCIOLI G; BARBIERI P; MAZZONI M; MENEGALE G; TRIPPI D |
| Titolo: | CONTROLLED MULTI-CENTER TRIAL OF TIOPRONIN AND D-PENICILLAMINE FOR RHEUMATOID-ARTHRITIS |
| Anno del prodotto: | 1982 |
| Digital Object Identifier (DOI): | 10.1002/art.1780250803 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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