Fifty-seven patients took part in a controlled double-blind trial between tiopronin and D-penicillamine as basic treatment for rheumatoid arthritis. Thirty-nine (19 receiving tiopronin, 20 receiving D-penicillamine) completed the trial after 1 year. Both drugs resulted in a decrease of the erythrocyte sedimentation rate, Ritchie index, and Lee index and in a sparing effect on symptomatic antiinflammatory therapy. Improvement in these variables was statistically highly significant at any interval with tiopronin, but was sometimes less or not at all significant with D-penicillamine. Nevertheless, the difference in effects between the 2 drugs never reached statistical significance. Six patients receiving tiopronin and 6 receiving D-penicillamine were taken out of the experiment because of side effects.
|Autori:||PASERO G; PELLEGRINI P; AMBANELLI U; CIOMPI M; COLAMUSSI V; FERRACCIOLI G; BARBIERI P; MAZZONI M; MENEGALE G; TRIPPI D|
|Titolo:||CONTROLLED MULTI-CENTER TRIAL OF TIOPRONIN AND D-PENICILLAMINE FOR RHEUMATOID-ARTHRITIS|
|Anno del prodotto:||1982|
|Digital Object Identifier (DOI):||10.1002/art.1780250803|
|Appare nelle tipologie:||1.1 Articolo in rivista|