Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.
|Autori:||M. J. Gualtieri; N. Malafronte; A. Vassallo; A. Braca; R. Cotugno; M. Vasaturo; N. De Tommasi; F. Dal Piaz|
|Titolo:||Bioactive limonoids from the leaves of Azaridachta indica (Neem)|
|Anno del prodotto:||2014|
|Digital Object Identifier (DOI):||10.1021/np400863d|
|Appare nelle tipologie:||1.1 Articolo in rivista|