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EnglishDefective DNA mismatch repair proteins fail to correct replication errors (RERs). These defects may lead to secondary, mutation of oncogenes and tumor suppressor genes. Microsatellite instability might be a marker of such replication errors. Eighteen rectal tumors were examined to evaluate genetic instability, in sporadic rectal cancer by PCR. RERs were observed in 27.8% of the cases. No significant difference was noticed between RER+ and RER- patients as far as prognosis, clinicopathological features and p53 gene mutation are concerned. The incidence of nm23 gene mutation was the only statistically significant difference between the 2 groups. Three patients with only one altered microsatellite showed advanced tumor and nm23 gene mutation. Two cases with 5 altered microsatellites and nm23 gene mutated are disease-free: in one of them the p53 gene was also mutated. Probably more than one altered microsatellite is necessary to protect from the effects of secondary mutations.
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| Autori: | INDINNIMEO M; CICCHINI C; STAZI A; MINGAZZINI P; CALIGO MA; GHIMENTI C; BEVILACQUA G |
| Titolo: | Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma |
| Anno del prodotto: | 1998 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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