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EnglishThis study examined the in vitro antiangiogenic effects of the somatostatin analog octreotide on the growth of human HUV-EC-C endothelial cells and vascular cells from explants of rat aorta cultured on fibronectin-coated dishes or included in fibrin gel. A total 10(-9) mol/L octreotide reduced the mean uptake of 3H-thymidine by HUV-EC-C cells by 37% compared with controls. The 10(-8) mol/L concentration of octreotide inhibited the proliferation of endothelial and smooth muscle cells growing on fibronectin by 32.6% and reduced the sprouting of cells from the adventitia of aortic rings in fibrin by 33.2% compared with controls, as measured by tetrazolium bioreduction and image analysis, respectively. These results demonstrate that octreotide is an effective inhibitor of vascular cell proliferation in vitro.
| Autori interni: | |
| Autori: | DANESI R; DEL TACCA M |
| Titolo: | The effects of the somatostatin analog octreotide on angiogenesis in vitro |
| Anno del prodotto: | 1996 |
| Digital Object Identifier (DOI): | 10.1016/S0026-0495(96)90080-3 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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