The aim of this study was to evaluate the possibility of predicting creatinine clearance (C-Cr) from plasma creatinine (P-Cr) and body com-position analysis by means of electrical impedance, thereby avoiding urine collection. Fat-free mass (FFM) and body cell mass (BCM) were measured in 50 renal patients (M29, F21; aged 17-74 years; mean 52.6) with different degrees of renal function (P-Cr 0.8-9.0 mg/dL, mean 2.13) by using a tetrapolar impedance plethysmograph. The relationship between 24 h urinary creatinine excretion (U-Cr) and FFM and BCM was evaluated in 20 of the above reported patients (MI I, F9; Pcr 08-9.0 mg/dL, mean 2.27). The mean ratio of 24 h U-Cr/FFM was 25.6 mg/kg in males and 22.5 in females and that of 24 h U-Cr/BCM was 51.9 mg/kg in males and 48.1 in, females. C-Cr was estimated in the remaining 30 patients (M18, F12; P-Cr, 0.9-8.8 mg/dL mean 2.04) from individual FFM and BCM values and P-Cr. In the same patients C-Cr was predicted also according to the Cockcroft and Gault formula and, for comparison, was measured with the conventional method by collecting 24 h urine. C-Cr predicted from the values of FFM and BCM gave a good estimate of 24h C-Cr more precise than that of Cockcroft and Gault C-Cr. Also, the repeatability of the predicted C-Cr was clearly better than that of 24 h C-Cr. In conclusion, creatinine clearance can be predicted, avoiding urine collection, from plasma creatinine and body composition analysis by means of electrical impedance.
|Autori interni:||TRAMONTI, GIANFRANCO|
|Autori:||Donadio C; Lucchesi A; Tramonti G; Bianchi C|
|Titolo:||Creatinine clearance can be predicted from plasma creatinine and body composition analysis by means of electrical bioimpedance|
|Anno del prodotto:||1998|
|Digital Object Identifier (DOI):||10.3109/08860229809045113|
|Appare nelle tipologie:||1.1 Articolo in rivista|