New Chiral Inhibitors of Induced Platelet Aggregation: the Enantiomeric Specificity of (R)- and (S)-Methyl and Ethyl Esters of 1-{p-[(1-Hydroxycarbonyl)-ethyloxy]-benzyl}-1H-1,2,3-triazole as a Tool for Determining their Biological Target.

Biagi, G; Giorgi, Irene; Catalani, R; Gervasi, O; Livi, O; Scartoni, V.

The synthesis of title enantiomers was accomplished and their biological behaviour as inhibitors of rabbit platelet aggregation process induced by ADP and arachidonic acid was determined. Structure-activity comparison with that of SM-12502 [(2R,5S)-(+)3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride] and Dazoxiben {4-[2-(1H-imidazol-1-yl)-ethoxy]-benzoic acid} allowed us to formulate the possible capability for the synthesized compounds to interact with the biological targets of the model molecules.

Autori interni:	Biagi G GIORGI, IRENE Catalani R Gervasi O Livi O Scartoni V. mostra contributor esterni nascondi contributor esterni
Autori:	Biagi G; Giorgi I; Catalani R; Gervasi O; Livi O; Scartoni V
Titolo:	New Chiral Inhibitors of Induced Platelet Aggregation: the Enantiomeric Specificity of (R)- and (S)-Methyl and Ethyl Esters of 1-{p-[(1-Hydroxycarbonyl)-ethyloxy]-benzyl}-1H-1,2,3-triazole as a Tool for Determining their Biological Target.
Anno del prodotto:	1996
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11568/45415

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