The synthesis of title enantiomers was accomplished and their biological behaviour as inhibitors of rabbit platelet aggregation process induced by ADP and arachidonic acid was determined. Structure-activity comparison with that of SM-12502 [(2R,5S)-(+)3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride] and Dazoxiben {4-[2-(1H-imidazol-1-yl)-ethoxy]-benzoic acid} allowed us to formulate the possible capability for the synthesized compounds to interact with the biological targets of the model molecules.
New Chiral Inhibitors of Induced Platelet Aggregation: the Enantiomeric Specificity of (R)- and (S)-Methyl and Ethyl Esters of 1-{p-[(1-Hydroxycarbonyl)-ethyloxy]-benzyl}-1H-1,2,3-triazole as a Tool for Determining their Biological Target.
GIORGI, IRENE;
1996-01-01
Abstract
The synthesis of title enantiomers was accomplished and their biological behaviour as inhibitors of rabbit platelet aggregation process induced by ADP and arachidonic acid was determined. Structure-activity comparison with that of SM-12502 [(2R,5S)-(+)3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride] and Dazoxiben {4-[2-(1H-imidazol-1-yl)-ethoxy]-benzoic acid} allowed us to formulate the possible capability for the synthesized compounds to interact with the biological targets of the model molecules.File in questo prodotto:
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