The impairment of humoral immunity with rapid turn-over of cellular B clones in children with HIV infection is known as well as the conduct of LDH isoenzymes in B cell lymphoproliferative diseases like Burkitt's lymphoma. Therefore, serum lactate-dehydrogenase activity (LD, EC 188.8.131.52) and its isoenzymes have been evaluated twice (within 12 months) in 11 children with HIV infection with respect to a control group (30 subjects). Furthermore, the relationship between those and other clinical and immunologic parameters (total lymphocytes, CD4/CD8, immunoglobulins, classification according to the Atlanta CDC 1987) has been studied. HIV infected children have shown a significant decrease in LD1 rates, which was directly correlated to CD4/CD8 values. After the follow-up, this correlation became even more significant. Thus, these findings may suggest the usefulness of LDH isoenzymes evaluation as a marker of disease activity in children with HIV infection.
|Autori:||Pifferi; M; Baldini; M; Cappuccio; A; Consolini R; Innocenti; B|
|Titolo:||Serum lactate-dehydrogenase isoenzymes in HIV positive children. A longitudinal study|
|Anno del prodotto:||1996|
|Digital Object Identifier (DOI):||10.1016/S0145-2126(97)00048-9|
|Appare nelle tipologie:||1.1 Articolo in rivista|