Rat submandibular salivary glands (SSG) contain a compound displaying insulin-like immunoreactivity (ILI) and various biological activities of insulin. As SSG ILI levels were reported to be increased in streptozotocin (STZ)-induced diabetes but not normalized by a two-week insulin treatment, we decided to check whether another antidiabetic treatment, vanadyl sulphate (VOSO4), was able to regulate SSG ILI concentration. A short term (8 days) i.p. VOSO4 treatment (total dose = 1.3 mmol/kg) of rats made diabetic 8 days earlier by a single i.v. injection of STZ (60 mg/kg BW) was able to induce a long-term (4 weeks) correction of hyperglycemia while weight gain was re-established. In untreated diabetic animals (approximate to-25%) and increased (approximate to+175%) as compared to normal rats. Both parameters were normalized in VOSO4-treated diabetic rats.
|Autori:||Deville de Periere D; Poucheret P; Egea JC; Gross R; Masiello P; Cros G; Serrano JJ; Ribes G|
|Titolo:||Vanadyl treatment normalizes submandibular salivary gland insulin-like immunoreactivity in streptozotocin-diabetic rats|
|Anno del prodotto:||1998|
|Digital Object Identifier (DOI):||10.1055/s-2007-978855|
|Appare nelle tipologie:||1.1 Articolo in rivista|