A novel neural network clustering algorithm, CoRe, is benchmarked against previously published results on a breast cancer data set and applying the method of Partition Around Medoids (PAM). The data serve to compare the samples partitions obtained with the neural network, PAM and model-based algorithms, namely Gaussian Mixture Model (GMM), Variational Bayesian Gaussian Mixture (VBG) and Variational Bayesian Mixtures with Splitting (VBS). It is found that CoRe, on the one hand, agrees with the previously published partitions; on the other hand, it supports the existence of a supplementary cluster that we hypothesize to be an additional tumor subgroup with respect to those previously identified by PAM
Are Model-based Clustering and Neural Clustering Consistent? A Case Study from Bioinformatics
BACCIU, DAVIDE;STARITA, ANTONINA
2008-01-01
Abstract
A novel neural network clustering algorithm, CoRe, is benchmarked against previously published results on a breast cancer data set and applying the method of Partition Around Medoids (PAM). The data serve to compare the samples partitions obtained with the neural network, PAM and model-based algorithms, namely Gaussian Mixture Model (GMM), Variational Bayesian Gaussian Mixture (VBG) and Variational Bayesian Mixtures with Splitting (VBS). It is found that CoRe, on the one hand, agrees with the previously published partitions; on the other hand, it supports the existence of a supplementary cluster that we hypothesize to be an additional tumor subgroup with respect to those previously identified by PAMI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.