Glioblastoma (GB, grade IV astrocytoma) is highly proliferating, infiltrating, and relapsing. So far, no therapy cures the disease and on average lethality occurs within 2 years from diagnosis. Despite the intimate molecular mechanisms of GB remain unknown, the mammalian Target Of Rapamycin (mTOR) is constantly upregulated within GB and in other astrocytomas. Consistently, mTOR was proposed as a target to cure GB.
|Titolo:||Rapamycin induces neuronal differentiation and decreases prion-like proteins in human glioblastoma cell cultures|
|Autori interni:||FERRUCCI, MICHELA|
|Anno del prodotto:||2013|
|Appare nelle tipologie:||4.2 Abstract in Atti di convegno|