Glioblastoma (GB, grade IV astrocytoma) is highly proliferating, infiltrating, and relapsing. So far, no therapy cures the disease and on average lethality occurs within 2 years from diagnosis. Despite the intimate molecular mechanisms of GB remain unknown, the mammalian Target Of Rapamycin (mTOR) is constantly upregulated within GB and in other astrocytomas. Consistently, mTOR was proposed as a target to cure GB.
Rapamycin induces neuronal differentiation and decreases prion-like proteins in human glioblastoma cell cultures
FERRUCCI, MICHELA;LAZZERI, GLORIA;FALLENI, ALESSANDRA;GUAGNOZZI, MARIANGELA;PAPARELLI, ANTONIO
2013-01-01
Abstract
Glioblastoma (GB, grade IV astrocytoma) is highly proliferating, infiltrating, and relapsing. So far, no therapy cures the disease and on average lethality occurs within 2 years from diagnosis. Despite the intimate molecular mechanisms of GB remain unknown, the mammalian Target Of Rapamycin (mTOR) is constantly upregulated within GB and in other astrocytomas. Consistently, mTOR was proposed as a target to cure GB.File in questo prodotto:
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