Nano-drug delivery systems based on polymeric biomaterials have received considerable interest as drug delivery vehicles [1]. The preclinical and clinical studies have demonstrated that drug-loaded polymeric nanoparticles confer prolonged circulation time, protection of the drug from physiological degradation, enhanced accumulation in the tumor sites, reduced side effects, improved drug tolerance, and/or long term drug bioavailability [2]. In this work new acrylate-based nanoparticles (NPs) were synthesized and characterized. The ability of the NPs to load and then release a drug was also investigated. In addition, the NPs were functionalized to obtain an active targeting.

Development and characterization of new intelligent nanoparticles for drug targeting

BELLOTTI, ELENA;BARBANI, NICCOLETTA;CASCONE, MARIA GRAZIA;CRISTALLINI, CATERINA
2014-01-01

Abstract

Nano-drug delivery systems based on polymeric biomaterials have received considerable interest as drug delivery vehicles [1]. The preclinical and clinical studies have demonstrated that drug-loaded polymeric nanoparticles confer prolonged circulation time, protection of the drug from physiological degradation, enhanced accumulation in the tumor sites, reduced side effects, improved drug tolerance, and/or long term drug bioavailability [2]. In this work new acrylate-based nanoparticles (NPs) were synthesized and characterized. The ability of the NPs to load and then release a drug was also investigated. In addition, the NPs were functionalized to obtain an active targeting.
2014
Bellotti, Elena; Barbani, Niccoletta; Cascone, MARIA GRAZIA; Cristallini, Caterina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/496273
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