Both enantiomers of cis-(+/-)-2,3-epoxyheptane 1a, cis-3,4-epoxyheptane 1b, cis-3,4-epoxynonane 1c, cis-3,4-epoxynonane-1-ol Id, and cis-1-methoxy-3,4-epoxynonane le undergo a highly stereoselective microsomal epoxide hydrolase catalysed hydration at the (S) carbon to give the corresponding three (R,R)-diol at complete conversion. A total kinetic resolution of racemic epoxides is also obtained with la and 1e. (C) 1998 Elsevier Science Ltd. All rights reserved.
Deracemization of (+/-)-cis-dialkyl substituted oxides via enantioconvergent hydrolysis catalysed by microsomal epoxide hydrolase
CHIAPPE, CINZIA;
1998-01-01
Abstract
Both enantiomers of cis-(+/-)-2,3-epoxyheptane 1a, cis-3,4-epoxyheptane 1b, cis-3,4-epoxynonane 1c, cis-3,4-epoxynonane-1-ol Id, and cis-1-methoxy-3,4-epoxynonane le undergo a highly stereoselective microsomal epoxide hydrolase catalysed hydration at the (S) carbon to give the corresponding three (R,R)-diol at complete conversion. A total kinetic resolution of racemic epoxides is also obtained with la and 1e. (C) 1998 Elsevier Science Ltd. All rights reserved.File in questo prodotto:
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