INTRODUCTION: The clinical relevance of daytime sleepiness associated with carbamazepine (CBZ) and vigabatrin (VGB) was objectively assessed by the multiple sleep latency test (MSLT) and nocturnal sleep recordings. MATERIAL AND METHODS: Twenty-six patients with partial epilepsy and mean monthly seizure frequency of 4, aged 18 to 48 years, receiving chronic monotherapy with CBZ and subsequent VGB addition for 2 months (14 patients), were compared with a group of healthy subjects. Subjective daytime sleepiness was complained by 13 patients on CBZ monotherapy and 9 patients during VGB add-on treatment. RESULTS: No differences in nocturnal sleep parameters, but significantly shorter daytime sleep latencies at the MSLT, were detected in CBZ-treated patients as compared with healthy controls. Addition of VGB therapy did not further enhance objective daytime sleepiness. CONCLUSION: Some sleepiness occurs in chronically CBZ-treated epileptic patients, which can be objectively measured by the MSLT, but it is not aggravated by add-on VGB.
BONANNI, ENRICA (Primo)
IUDICE, ALFONSO (Penultimo)
|Autori:||Bonanni, Enrica; Massetani, R; Galli, R; Gneri, C; Petri, M; Iudice, Alfonso; Murri, Luigi|
|Titolo:||A quantitative study of daytime sleepiness induced by carbamazepine and add-on vigabatrin in epileptic patients|
|Anno del prodotto:||1997|
|Appare nelle tipologie:||1.1 Articolo in rivista|