Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect, However, all four compounds enhanced the frequency of c-mitoses.
|Autori:||TURCHI G; GLATT HR; SEIDEL A; PULITI A; SBRANA I|
|Titolo:||Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones|
|Anno del prodotto:||1997|
|Digital Object Identifier (DOI):||10.1023/A:1007302111081|
|Appare nelle tipologie:||1.1 Articolo in rivista|