Background: We compared the oncologic effectiveness of open adrenalectomy and endoscopic adrenalectomy in the treatment of patients with localized adrenocortical carcinoma. Methods: One hundred fifty-six patients with localized adrenocortical carcinoma (stage I/II) who underwent R0 resection were included in an Italian multiinstitutional surgical survey. They were divided into 2 groups based on the operative approach (either conventional or endoscopic). Results: One hundred twenty-six patients underwent open adrenalectomy and 30 patients underwent endoscopic adrenalectomy. The 2 groups were well matched for age, sex, lesion size, and stage (P = NS). The mean follow-up time was similar for the 2 groups (P = NS). The local recurrence rate was 19% for open adrenalectomy and 21% for endoscopic adrenalectomy, whereas distant metastases were recorded in 31% of patients in the conventional adrenalectomy group and 17% in the endoscopic adrenalectomy group (P = NS). The mean time to recurrence was 27 ± 27 months in the conventional open adrenalectomy group and 29 ± 33 months in the endoscopic adrenalectomy group (P = NS). No significant differences were found between the 2 groups in terms of 5-year disease-free survival (38.3% vs 58.2%) and 5-year overall survival rates (48% vs 67%; P = NS). Conclusion: The operative approach does not affect the oncologic outcome of patients with localized adrenocortical carcinoma, if the principles of surgical oncology are respected. © 2012 Mosby, Inc. All rights reserved.
|Autori interni:||RAFFAELLI, MARCO|
|Autori:||Lombardi C.P.; Raffaelli M. ; De Crea C.; Boniardi M.; De Toma G.; Marzano L.A.; Miccoli P.; Minni F.; Morino M.; Pelizzo M.R; Pietrabissa A; Renda A.; Valeri A.; Bellantone R.|
|Titolo:||Open versus endoscopic adrenalectomy in the treatment of localized (stage I/II) adrenocortical carcinoma: Results of a multiinstitutional Italian survey|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1016/j.surg.2012.08.014|
|Appare nelle tipologie:||1.1 Articolo in rivista|