The aim of the present research was to compare the pharmacokinetics of metoclopramide (MET)1 after intravenous (IV)2, intramuscular (IM)3, subcutaneous (SC)4 and per rectum (PR)5 administrations to normal rabbits. Six normal New Zealand white rabbits were used in a random cross-over design (4x4 Latin-square) with a 1-week washout period between trials. Each rabbit had been given MET by IV, IM and SC at 2 mg/kg, and PR administration at 4 mg/kg. The plasma concentrations of MET were determined by a HPLC. The mean plasma profiles of MET after IV, IM and SC administrations were similar. The bioavailability of MET via IM and SC was 96% and 112% respectively. The plasma concentrations within the PR group were quite variable resulting in an extremely low and variable bioavailability with an average of 12%. IM and SC administrations of MET may be useful in treating GI disorders in rabbits when venous access is not available but PR administration is likely to be unreliable.
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