Indomethacin and sulindac were used as tools to study the role of renal and/or systemic prostaglandins in the pharmacological response to atenolol. Patients receiving chronic treatment with atenolol 100 mg received indomethacin 50 mg twice daily or sulindac 200 mg twice daily in a randomised crossover trial. Indomethacin significantly reduced the antihypertensive action of atenolol while sulindac had no effect. The role that systemic and/or renal prostaglandins may play in the antihypertensive action of atenolol is discussed with reference to renal PGI2 production and inhibition of platelet cyclo-oxygenase.
|Autori:||Salvetti A; Pedrinelli R; Alberici P; Magagna A; Abdel-Haq B|
|Titolo:||The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients|
|Anno del prodotto:||1984|
|Appare nelle tipologie:||1.1 Articolo in rivista|